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KMID : 0980220130130030089
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Journal of the Korean Dental Society of Anesthesiology
2013 Volume.13 No. 3 p.89 ~ p.94
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EC50 of Remifentanil to Prevent Propofol Injection Pain
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Hong Hun-Pyo
Ko Hyun-Min
Yoon Ji-Young
Yoon Ji-Uk
Park Hun-Hyo
Roh Young-Chea
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Abstract
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Background: Various strategies have been studied to reduce the propofol injection pain. This study was designed to find out effect-site target concentration (Ce) of remifentanil at which there was a 50% probability of preventing the propofol injection pain (EC50).
Methods: Anesthesia was induced with a remifentanil TCI (Minto model). The Ce of remifentanil for the first patient started from 2.0 ng/ml. The Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by Dixon up-and-down method with the interval of 0.5 ng/ml. After the remifentanil reached target concentrations, propofol was administered via a target-controlled infusion system based on a Marsh pharmacokinetic model using a TCI device (Orchestra®; Fresenius-Vial, Brezins, France). The dose of propofol was effect site target-controlled infusion (TCI) of 3 μg/ml.
Results: The EC50 of remifentanil to prevent the propofol injection pain was 1.80 ± 0.35 ng/ml by Dixon’s up and down method.
Conclusions: The EC50 of remifentanil to blunt the pain responses to propofol injection was 1.80 ± 0.35 ng/ml for propofol TCI anesthesia.
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KEYWORD
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Injection, Pain, Propofol, Remifentanil
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